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Increased Risk of Hypertension
This result corresponds to a 30% higher likelihood of hypertension than average.
Not medical advice.
Medical Summary
AGT M235T elevates angiotensinogen expression, increasing RAAS tone and arterial pressure set-point. ACE and AGTR1 polymorphisms enhance sodium sensitivity and vascular resistance through altered signaling.
Genes
AGT · ACE · AGTR1
Confidence
Moderate
References (5)
GENE: APOE
| rsID | Genotype | Risk | Effect |
|---|---|---|---|
| rs429358 | ε4/ε4 | ~8-15x | Higher AD risk |
| ε3/ε4 | ~3-4x | Higher AD risk | |
| ε3/ε3 | Baseline | Baseline |
Gene Summary
Apolipoprotein E (APOE) encodes a lipid-binding protein critical in cholesterol transport, neuronal repair, and amyloid clearance. Isoforms as ε4 are associated with increased risk of late-onset Alzheimer's, but affects are influenced by lifestyle factors like diet and exercise.
Associated Traits
- Alzheimer's + LDL Cholesterol
- Exceptional Longevity
References (10 studies)
PMID: 34876989 • APOE ε4 and cholesterol in HDL/LDL ratios • Multi-ancestry analysis (23 studies)
You
"I have a family history of high blood pressure. Does my 30% increased risk mean I should be worried, or can lifestyle changes help?"
AI Powered Genetic Health Coach
"Great question! A 30% increased risk is moderate and highly modifiable. Your AGT, ACE, and AGTR1 variants affect sodium sensitivity and vascular tone — both respond well to lifestyle interventions.
What helps most:
• DASH diet (low sodium, high potassium)
• Regular aerobic exercise (150 min/week)
• Stress management
Studies show these changes can reduce hypertension risk by 40-60%, even with genetic predisposition. Want specific diet recommendations based on your other variants?"
THE PROCESS
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What You'll Discover
Explore Your Genetic Information Across Key Categories
Learn what research suggests about genetic variants related to stress, energy, cognitive function, fitness, nutrition, and longevity. All information is educational and not medical advice.
STRESS RESPONSE
What Your DNA May Reveal About Stress
Explore genetic variants that influence how your body processes cortisol and stress hormones. Understanding your COMT gene and related variants can provide educational insights into your natural stress response patterns.
COMT GENE
Involved in stress response pathways
ENERGY METABOLISM
Understanding Your Genes and Daily Energy
Learn how genetic variations in circadian rhythm genes like CLOCK and nutrient metabolism genes like FADS1 may influence energy patterns. This educational information can help you understand factors that may affect your daily vitality.
CLOCK & FADS1 GENES
Associated with circadian rhythm & metabolism
COGNITIVE FUNCTION
Exploring Genetic Factors in Brain Health
Discover what research shows about variants in genes like APOE and BDNF related to memory, learning, and brain aging. This educational content helps you understand genetic factors that researchers associate with cognitive function.
APOE GENE
Studied in brain health research
FITNESS & PERFORMANCE
Understand Your Athletic Potential
Discover genetic variants linked to muscle fiber types (ACTN3), VO2 max capacity, and recovery speed. Research shows these genes may influence your natural strengths in endurance vs. power activities.
ACTN3 GENE
The "speed gene" linked to fast-twitch muscle fibers
NUTRITION INSIGHTS
How Your Genes Process Food
Learn about genetic factors affecting lactose tolerance, caffeine metabolism, vitamin D absorption, and gluten sensitivity. Understanding these variants can provide educational context for your dietary choices.
LCT GENE
Influences lactose tolerance in adults
LONGEVITY FACTORS
Genetic Insights on Healthy Aging
Explore research on genes associated with telomere length, cellular aging, and longevity. Genes like FOXO3 and APOE are studied for their roles in lifespan and age-related health.
FOXO3 GENE
Associated with longevity in centenarian studies
Why ExomeDNA
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